DEUTERIUM-ENRICHED MEMANTINE - Patent - The present application describes deuterium-enriched memantine pharmaceutically acceptable salt forms thereof
The present application describes deuterium-enriched memantine,
pharmaceutically acceptable salt forms thereof, and methods of treating
using the same., is selected from at least 5%, at least 10%,
at least 14%, at least 19%, at least 24%, at least 29%, at least 33%, at
least 38%, at least 43%, at least 48%, at least 52%, (k) at least 57%, at
least 62%, at least 67%, at least 71%, at least 76%, at least 81%, at
least 86%, at least 90%, at least 95%, and 100%.
The present invention is based on increasing the amount of deuterium
present in memantine above its natural abundance. This increasing is
called enrichment or deuterium-enrichment. If not specifically noted, the
percentage of enrichment refers to the percentage of deuterium present in
the compound, mixture of compounds, or composition.
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