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Safety and tolerability of once-daily versus twice...[Int J Geriatr Psychiatry. 2007] - PubMed Result
Safety and tolerability of once-daily versus twice-daily memantine: a randomised, double-blind study in moderate to severe Alzheimer's disease.OBJECTIVE: To assess the safety and tolerability of three different dosing schedules of memantine in patients with moderate to severe Alzheimer's disease (AD). METHOD: This 12-week, randomised, double-blind study, investigated three dosing schedules of memantine: OD1 (20 mg once daily with a 1-step up-titration); OD3 (20 mg once daily with a 3-step up-titration); and BID3 (10 mg twice daily with a 3-step up-titration as currently recommended in the memantine labelling). The study comprised 78 patients with moderate to severe AD (DSM-IV-TR criteria; MMSE score or = 18), 70% of whom were on stable dosing of acetylcholinesterase inhibitor (AChEI) initiated or = 3 months prior to study start.
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26 july 2008
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Forest Laboratories, Inc Q1 2009 Earnings Call Transcript
Seeking Alpha - Apr 21, 2009
The NDA for memantine ER is completed and waiting in the wings as we continue to monitor the patent litigation activities around Namenda. ...
FRX
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