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Memantine Dosing Senior Health Sitemap When starting memantine, dosing usually begins at 5 mg, taken once daily. Your healthcare provider will gradually increase your dosage every week until the full dose is reached. The full recommended dose of memantine is 10 mg twice a day. Memantine dosing may be lower for certain people, such as those with severe kidney problems.The starting dose of memantine is 5 mg once daily. After at least a week, your healthcare provider can increase the dose to 5 mg twice daily. After another week, your healthcare provider can again increase the dose -- to 15 mg of memantine total per day (split into two doses per day: 5 mg and 10 mg). Finally, after one more week, your healthcare provider can increase you to the full recommended dose of 10 mg twice daily.The NMDA antagonist memantine affects training ind...[BMC Neurosci.