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Vibramycin Drug Information, Professional
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. Doxycycline and minocycline are generally no more effective in the initial treatment of acne, are more likely to cause photosensitivity reaction, and are more expensive than tetracycline; however, doxycycline and minocycline may be taken less frequently per day than tetracycline
After reconstitution, intravenous infusions of doxycycline hyclate retain their potency for 12 hours at room temperature or for 72 hours if refrigerated at concentrations of 100 mcg (0.1 mg) to 1 mg per mL in suitable fluids (see manufacturer's package insert). Intravenous infusions of doxycycline hyclate retain their potency for 6 hours at room temperature at concentrations of 100 mcg (0.1 mg) to 1 mg per mL in lactated Ringer's injection or 5% dextrose and lactated Ringer's injection. Infusions must be protected from direct sunlight during administration.