Injection of Tacrolimus - Patent Application 20080125456 This invention relates to tacrolimus injection comprising tacrolimus as an active ingredient, macrogol 15 hydroxystearate as a surfactant and a non-aqueous solvent. The conventional tacrolimus formulations have been chiefly prepared in a solid form such as capsule, but there are many approaches to improve dissolution rate because of insolubility of the drug, via grind of drug particles, enhancement of drug solubility not only by the addition of a surfactant, but also by the manufacture of microemulsion or solid dispersion formulations.
