Tacrolimus Search our site | NewsEquipment | Books | Your Experience | Other resources | Glossaries Women must avoid getting pregnant while taking tacrolimus. Hormonal contraceptives such as the pill, injection, implant or intra-uterine progestogen-only system (IUS), may be less effective. Ask your doctor or pharmacist about suitable alternative methods of contraception. (passing water), seeing or hearing things that are not there, headache, chest pain or tightness, fast or fluttering heartbeat, heart problems, itching, loss of appetite, weight loss or weight gain, loss of energy or weakness, kidney problems, tremor, increased or decreased blood pressure, blood sugar changes, feeling depressed, emotional changes, mental disorders, excess of body fluid, angina, trembling, joint pain, hair loss, acne, nervousness, sensitivity to light, loss of co-ordination, wheezing, shortness of breath, cough, swelling of feet or lower legs, tingling, excess hair growth, trouble sleeping, unusual bleeding or bruising, yellowing of skin, liver problems, unusual tiredness, pale skin, visual disturbances, muscle cramps and stiffness, numbness or pain in the legs, feet, arms or hands, ringing in ears and hearing changes, reduced consciousness, sweating, a general feeling of discomfort or illness, dehydration and thirst, speech and language problems, memory problems, menstrual disturbances and skin disorders. If you experience these or any other worrying symptoms, which you think may be due to this medicine, discuss them with your doctor or pharmacist.