Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroidsCorrespondense: Dr D. A. Hesselink, Department of Internal Medicine, Renal Transplant Unit, Room D 412, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands. Tel.: + 31 10 4639222; Fax: + 31 10 4089461; E-mail: ) is recommended and target ranges have been defined [2]. Nevertheless, in everyday clinical practice new and sometimes life threatening interactions with tacrolimus [3] are encountered. These interactions may result in increased or decreased drug concentrations or in altered pharmacodynamic effects of tacrolimus, and deserve further and continued attention [4, 5].
