Topical Tacrolimus Is An Effective Alternative to Steroids for EczemaTopical Tacrolimus Is An Effective Alternative to Steroids for EczemaA 40-year-old male brings his two sons to see you in clinic, ages 6 and 7 with moderately severe eczema. Both have had moderately successful courses with corticosteroids in the past, but he wants to know if there is any other treatment you would prescribe for his sons. In children with moderately severe eczema, is topical tacrolimus more effective than steroids? Eighteen of the 180 patients discontinued treatment early; 7 in the vehicle group, 2 in 0.03% tacrolimus group, 5 in the 0.1% group, and 4 in the 0.3 % group. 4 of the 7 patients in the vehicle group and one patient in the tacrolimus group discontinued treatment because of perceived lack of efficacy, 2 of 44 and 5 of 136 discontinued treatment because of adverse events and noncompliance accounted for 1 patient in the vehicle group and 5 in the tacrolimus groups.
