Tacrolimus (Protopic Ointment) Drug Information by eDrugSearch A B C D E F G H I J K L M N O P Q R S T U V W X Y Z View All Switching Patients From Twice-Daily to Daily Tacrolimus Appears ...DG NewsBy Cameron Johnston COPENHAGEN, Denmark -- April 25, 2009 -- Switching stable liver transplant recipients from twice-daily tacrolimus to a once-daily extended release daily formulation appears to be safe and effective, researchers stated here at the ...: As noted in the FDA Alert, FDA has issued a public health advisory to inform healthcare professionals about a potential cancer risk from use of Protopic. This concern is based on information from animal studies, case reports in a small number of patients, and knowledge of how drugs in this class work. The potential for systemic immunosuppression is unknown and the role of Protopic in the development of the cancer-related events in the individual patient reports is also uncertain at this. Animal studies have showed that skin tumors formed faster in animals treated with tacrolimus, the active ingredient in Protopic, and exposed to light. Because of this, you should limit exposure to natural or artificial sunlight, such as sunlamps or tanning beds.