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Prograf (injection) - Tacrolimus - Medical DrugHome Drugs Supplements Drugs (Listed by Trade Name) Prograf (injection)Prograf (tacrolimus) is a medication often used in people who have had a kidney, liver, heart or lung transplanted from someone else because their own was not functioning properly. Prograf is referred to as an immunosuppressant medication because it helps stop the immune system from recognising a transplanted organ as foreign. By doing this Prograf therefore prevents the transplanted organ from being attacked by the immune system.Tacrolimus is a medication with a complicated dosage. Most drugs have a simple range in which the dose is too high (a toxic dose), too low (the drug simply doesn't work), or in between (the appropriate dose). The amount of tacrolimus taken, however, doesn't always fit exactly with the amount in the body. As a result, doctors are quite careful in ways that aren't usually necessary for other medications. It is recommended that the amount of tacrolimus in your blood be directly checked by means of a blood test after a few days on the medication, and at certain intervals afterwards. Because of these results, your dose might change. This is important - it keeps side effects to a minimum and makes sure you are getting the most out of the medication.