Donepezil is ineffective in long term treatment of dementia Donepezil is ineffective in long term treatment of dementia Home Help Search Archive Feedback Table of Contents Author Keyword(s) Vol Page [Advanced] BMJ 2004;329 (30 October), doi:10.1136/bmj.329.7473.0-g This article PDF Respond to this article Read responses to this article Alert me when this article is cited Alert me when responses are posted Alert me when a correction is posted Services Email this article to a friend Find similar articles in BMJ Add article to my folders Download to citation manager Articles citing this Article Filler POEM * Donepezil is ineffective in long term treatment of dementia Question Does donepezil provide clinically meaningful benefits in typical patients with Alzheimer's disease? Synopsis This relatively complex randomised controlled trial (double blinded, with concealed allocation) had multiple phases designed to evaluate community dwelling elderly people with mild to moderate Alzheimer's disease (DSM-IV criteria). To start, 565 patients were randomised to receive 12 weeks of donepezil 5 mg daily or placebo.
