Aricept ODT - Uses, Side effects, Interactions, Warnings, Indications - Health - redOrbit . Donepezil does not cure Alzheimer's disease. It works in the brain to improve thinking, memory, attention, and the ability to do simple tasks.. This chemical is thought to be important for the processes of learning and memory. Donepezil prevents the breakdown of acetylcholine, thereby increasing its levels in the brain. Donepezil is of the most benefit in mild to moderate disease and is of little benefit when the disease becomes severe.