Solid dispersion of tacrolimus invention * Get notified when a new patent matches your "search terms". More info...The present invention relates to the carrier of the solid dispersion of tacrolimus, which is prepared by using the solid surfactant having a property of HLB value higher than or equal to about 7. The surfactants carry out a function of a carrier and a function of a dissolution enhancer, simultaneously. As a result, the dissolution rate of tacrolimus is improved, and the oral absorbability and the bioavailability may be increased due to rapid drug release. (end of abstract)[0002] There have been numerous efforts to improve dissolution rate of water-insoluble drug. These include, (a) reducing drug particle size to increase surface area, (b) solubilization in surfactant, (c) forming into micro-emulsion, (d) decreasing crystallinity of drug by formation of solid dispersion, and so on. The solid dispersion is a pharmaceutical formulation of an amorphous drug was dispersed in a solid carrier. To prepare solid dispersion, it was prepared by dissolving drug and solid carrier in organic solvent or fusing them, and then drying or cooling.
