TACROLIMUS OPTHALMIC

Mary Ann Liebert, Inc. - Journal of Ocular Pharmacology and Therapeutics - 24(3):333 Hello. Sign in to personalize your visit. New user? Register now. Eriko Fujita, Yoshinori Teramura, Koichi Mitsugi, Shin-Ichi Ninomiya, Takafumi Iwatsubo, Akio Kawamura, Hidetaka Kamimura. Journal of Ocular Pharmacology and Therapeutics. June 2008, 24(3): 333-343. doi:10.1089/jop.2007.0086. : Results for single and repeated instillation studies were similar. In eyeball microautoradiograms, 15 min after dosing, the level of radioactivity in the cornea was the highest, followed by conjunctiva. After 1 h, little specific distribution was detected in the corneal epithelium, stroma, or Descemet's membrane. At 24 h, the level of radioactivity in the cornea decreased. Whole-body autoradiograms showed that the radioactivity was distributed to the digestive tract through the nasal meatus and esophagus and then was excreted into the feces. In the i.v. dose study, the distribution of radioactivity in whole-body autoradiographs was similar to that in quantitative tissue distribution measurements. The excretion of radioactivity in the urine and feces up to 168 h were 4.5 and 94.9%, respectively.