Tacrolimus Ointment (Protopic®) for Atopic Dermatitis Volume 14 - 2009 Articles Volume 13 - 2008 Articles Volume 12 - 2007 Articles Volume 11 - 2006 Articles Volume 10 - 2005 Articles Acne Treatment Cold Sores Treatment Eczema Treatment Fungal Treatment Psoriasis Treatment Psoriatic Arthritis Treatment Rosacea Treatment Skin Cancer Treatment Skin Care Treatments Bacterial Infection Treatment Lice Treatment Herpes Treatment Lupus Treatment Wart Treatment , Fujisawa) is an effective agent in a class of topical immunomodulators. Its mechanism of action is based on calcineurin inhibition, which results in decreased T-cell activation and inflammatory cytokine release. Tacrolimus ointment is safe and effective for short- and long-term treatment of atopic dermatitis (AD) in pediatric and adult patients. The most common adverse events associated with its use are a transient burning sensation and pruritus at the site of application. Unlike topical corticosteroid agents, tacrolimus ointment does not cause a reduction in collagen synthesis or skin thickness. Because tacrolimus ointment does not cause skin atrophy, it may be safely used for months or years on all skin areas, including the face and intertriginous areas.
