Drug InfoNet - Prograf - [liver]Drug Infonet provides drug and disease information for your healthcare needs. Visit our FAQ page to find answers to common health questions. Look on the Manufacturer Info page to link to pharmaceutical company pages. Click to Health Info and Health News for the latest in healthcare developments. Prograf (tacrolimus) is a drug used to suppress humoral immunity in grafted patients. It does this mainly (with current information) by impairing T cell immunity. Dose dependent diabetes mellitus has been reported in 20-30% of patients. The drug can cause neuro and renal toxicity, and this appears fairly dose dependent. As a consequence, it needs to be used with great care when used with other drugs which affect renal function (cyclosporin for example). Heart enlargement has also been reported and there is a definite increase in malignancies with patients taking this drug (as well as most immunosuppressives).
