Prescription Assistance Prograf | Other Medications in Antibiotics GroupPrograf (Tacrolimus) is used for the prevention of rejection of transplanted organs. Prograf is a drug that suppresses the immune system and is used to prevent rejection of transplanted organs. Prograf accomplishes its immune-suppressing effecting by inhibiting an enzyme (calcineurin) crucial for the multiplication of T-cells, cells that are vital to the immune process. The use of oral Prograf allows transplantation specialists to reduce the dose of steroids which are also used to prevent rejection. This "steroid-sparing effect" is important because of the many side effects that can occur when larger doses of steroids are used for a long period of time. Prograf was approved by the FDA in April, 1994 for liver transplantation and also has been used in patients for heart, kidney, small bowel, and bone marrow transplantation.
