PROGRAF tacrolimus capsules and injection | Healthcare ProfessionalsThe dosing recommendations presented below are guidelines. Dosing should be adjusted based on clinical assessments of rejection and tolerability. The relative risk of toxicity for example, nephrotoxicity and new-onset diabetes mellitus is increased with higher trough concentrations. Monitoring of whole blood trough concentrations is considered an essential aid to patient management for the evaluation of rejection, toxicity, dose adjustments, and adherence. (tacrolimus) is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver, kidney, or heart transplants. It is recommended that Prograf be used concomitantly with adrenal corticosteroids. Because of the risk of anaphylaxis, Prograf injection should be reserved for patients unable to take Prograf capsules orally. In heart transplant recipients, it is recommended that Prograf be used in conjunction with azathioprine or mycophenolate mofetil. The safety and efficacy of the use of Prograf with sirolimus has not been established.
