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PROGRAF tacrolimus capsules and injection | Patients & Caregivers (tacrolimus) was discovered in 1984 by Fujisawa scientists in Tsukuba, Japan. Its discovery helped transform the success of transplantation, making it an option that more people could benefit from.Prograf was approved for the prevention of organ rejection in liver transplant recipients in 1994, in kidney transplant recipients in 1997, and in heart transplant recipients in 2006. Over the years, it has helped many people enjoy greater transplant success many of whom continue to share their stories today.