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Liver Medication: Prograf (tacrolimus) PROGRAF is prescribed to prevent or treat organ rejection in people who have received liver transplants. It is used for long-term (perhaps lifetime) immunosuppression. The benefits of taking this medication if a patient is pregnant or breast feeding must be weighed against the potential hazards to her, her fetus, or her infant. A woman who thinks she is pregnan should consult the transplant team immediately.