Generic Prograf 0.5mg, 1mg Medication Side Effects and Interaction InformationSide Effects/ Side Affect of Generic for Prograf (Tacrolimus) Generic Prograf is a medication used to decrease the immune system response. Generic Prograf is used to reduce immune responses and prevent rejection in patients who receive organ or bone marrow transplants.Some of the most serious Generic Prograf side effects include signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine, signs of decreased red blood cells - unusual weakness or tiredness, fainting spells, lightheadedness, blurred vision, increased sensitivity of the eyes to light, burning or tingling in the hands or feet, difficulty breathing, wheezing, frequent urination, increased thirst or hunger, ringing in he ears, skin rash or itching (hives), seizures (convulsions),stomach, back or general pain, swelling of the feet or legs, unusual or sudden weight gain, yellowing of skin or eyes.