Astellas Pharma Canada, Inc.SITEMAP | WORLDWIDE | FRAN AIS | HOME Your doctor, nurse, and pharmacist have explained Prograf to you, and this information will answer some of the questions you may have about your new medication. The success of treatment with this drug depends on how carefully you follow your doctor s instructions. As you review this information, write down any questions that you may have. Then, talk with your doctor, nurse or pharmacist. This information should not replace your doctor s or pharmacist s advice. Be sure to tell your doctor right away if you notice any of these symptoms, and especially if they continue, bother you in any way, or seem to increase in intensity: diarrhea, nausea, vomiting, stomach pain; headache, tremors, convulsions, difficulty sleeping; pain and /or burning during urination which may be signs of a urinary tract infection; decreased or increased urine volumes, dark coloured urine which may be a sign of kidney problems or yellowing of the skin or eyes or back pain which may be a sign of liver problems; diabetes/increased blood sugar, swelling or tingling in your hands and feet; palpitations, abnormal heart rhythms, chest pain, high blood pressure; fever.