NIZORAL KETOCONAZOLE SHAMPOO

Hairloss-reversible.com: Ketoconazole Shampoo Nizoral-Fungoral benefits for AGA. Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia , Pierard-Franchimont et al, Dermatology 1998;196:474-477.In contrast, both present studies concur to show an unequivocable effect of a 2% KCZ shampoo on hair variables affected by AGA. Hair density and size, and proportion of anagen follicles were all improved. Although the number of subjects was limited in the second study, results obtained compare with minoxidil.Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. Based on these potent effects on gonadal function in vivo as well as previous work in vitro demonstrating affinity of ketoconazole for receptor proteins for glucocorticoids and 1,25 OH 2 vitamin D3 and for sex steroid binding globulin SSBG , the binding of ketoconazole to human androgen receptors AR in vitro was also examined. Ketoconazole competition with [3H]methyltrienolone R1881 for androgen binding sites in dispersed, intact cultured human skin fibroblasts was determined at 22 degrees C. Fifty percent displacement of [3H]R1881 binding to AR was achieved by 6.4 /- 1.8 SE x 10 -5 M ketoconazole. Additional binding studies performed with ketoconazole in the presence of increasing amounts of [3H]R1881 showed that the interaction of ketoconazole with AR was competitive when the data were analyzed by the Scatchard method. It should be noted, however, that the dose of ketoconazole required for 50% occupancy of the androgen receptor is not likely to be achieved in vivo, at least in plasma. Finally, androgen binding studies performed with other imidazoles, such as clotrimazole, miconazole, and fluconozole, revealed that in this class of compounds only ketoconazole appears to interact with the androgen receptor.