Flexyx: Nizoral Cream (Generic name - Ketoconazole) OnLine Information Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]Nizoral is used to treat a variety of fungal infections. Examples of these fungal infections include candida infections of the skin or mouth (thrush), blastomycosis, histoplasmosis, coccidiomycosis, and others. Nizoral is also used to treat fungal infections that have not responded to griseofulvin, another antifungal medication.Nizoral Cream interacts with 14- demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Nizoral Cream can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
