Lithium Carbonate (Lithium) - Drug Info, User Reviews, Side Effects, Research, Clinical Trials Summary Description Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage and Contraindications Clinical Pharmacology Other Rx Information Adverse Event Reports User Ratings / Reviews CONCLUSION: Allopurinol is clinically effective and well-tolerated adjunctively with lithium in manic episodes and may represent an alternative approach in the treatment of acute mania, especially for those presenting tolerability and safety issues with antipsychotics. The present results strongly support the involvement of the purinergic system in the pathophysiology and therapeutics of bipolar disorder. Further placebo-controlled studies with allo-purinol compared with standard mood stabilizers in mania and maintenance are warranted. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00560079.