Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Clinical Trials. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Clinical research trials and Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like OBJECTIVES: I. Compare the interval between completion of cancer treatment that included prophylactic cranial irradiation and onset of cognitive decline in patients with small cell lung cancer (SCLC) treated with donepezil and vitamin E vs placebo. II. Determine the toxicity of donepezil and vitamin E in these patients. III. Determine whether preserved cognitive function favorably impacts quality of life in these patients. IV. Determine the natural history of cognitive decline in these patients after cancer treatment. V.
