Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia - Full Text View - ClinicalTrials.gov First Received: September 8, 2005 Last Updated: December 4, 2008 History of Changes To document effectiveness, safety, and tolerability of donepezil in patients with mixed AD/VaD, and to further document the effectiveness, safety, and tolerability of donepezil in patients with VaD. The effects of donepezil on executive functioning, behavior, general cognition, ADLs and global functioning will be assessed.