Brain Pharm Data: Pathological mechanism.Donepezil modulates potassium channels This work was the first to show different effects of donepezil on two different types of potassium channels (I K(DR) and I K(A)) of molluscan neurons. At a low concentration (5 uM), the drug suppressed I K(DR) but augmented I K(A); at higher concentrations (10-100 uM), it reduced both current types. The ability of donepezil to reduce I K(DR) at low concentrations suggests the drug ability to prevent neurodegeneration in Alzheimer's disease. (Solntseva et al.