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StateMaster - Encyclopedia: Nootropic The top five states for youth voter turnout in the 2000 Presidential Election all went for Al Gore. Most alleged nootropic substances are nutrients or plant components (herbs, roots, beans, bark, etc.), available over the counter at health food and grocery stores, and are used as nutritional supplements. Some nootropics are drugs, used to treat people with cognitive learning difficulties, neural degradation (Alzheimer's disease or Parkinson's disease), and for cases of oxygen deficit to prevent hypoxia. These drugs have a variety of human enhancement applications as well, are marketed heavily on the World Wide Web, and are used by many people in personal cognitive enhancement regimens.Thinking is a biologically demanding task. It involves the firing of neurons, which requires ample neurotransmitters, and even though these are reuseable to some extent, they do get depleted. Depletion of neurotransmitters generally results in reduced mental performance, which may include difficulty concentrating, slowed reasoning, decreased learning efficiency, impaired recall, reduced coordination, lowered moods, inability to cope, increased response times, and mental fatigue. This also generally increases the likelihood of human error on tasks and activities performed. Stress causes neurotransmitters to be depleted even faster. The brain's neurotransmitters need to be replenished frequently, made by the body from substances ingested in the diet. Maintaining neurochemicals at optimal levels has a corresponding effect on brain performance, supporting improved mental agility and stamina, even beyond the individual's normal limits.