Complete Donepezil information from Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z The 10 mg dose, with 1-wk titration, is likely to be associated with a higher incidence of cholinergic adverse reactions than the 5 mg dose. With 6-wk titration, the frequency of these same adverse reactions was similar between 5 and 10 mg dosing. The following adverse reactions are based on 6-wk titration.