Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Clinical Trials. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Clinical research trials and Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including OBJECTIVES: I. Compare the interval between completion of cancer treatment that included prophylactic cranial irradiation and onset of cognitive decline in patients with small cell lung cancer (SCLC) treated with donepezil and vitamin E vs placebo. II. Determine the toxicity of donepezil and vitamin E in these patients. III. Determine whether preserved cognitive function favorably impacts quality of life in these patients. IV. Determine the natural history of cognitive decline in these patients after cancer treatment. V.
