Memorit - Prescribing InformationPHYSICIAN S PRESCRIBING INFORMATION Memorit is indicated for the treatment of mild to moderate dementia of the Alzheimer s type. The higher dose of 10 mg did not provide a statistically significantly greater clinical benefit than 5 mg. Nethertheless, there is a suggestion, based upon order of group mean scores and dose trend analyses of data from clinical trials, that a daily dose of 10 mg of donepezil might provide additional benefit for some patients. Accordingly, whether or not to employ a dose of 10 mg is a matter of prescriber and patient preference. There is evidence from controlled trials indicating that the 10 mg dose, with a one week titration, is likely to be associated with a higher incidence of cholinergic adverse events than 5 mg dose. In open label trials using a 6 week titration, the frequency of these same adverse events was similar between the 5 mg and 10 mg dose groups. Therefore, because steady state is not achieved for 15 days and because the incidence of untoward effects may be influenced by the rate of dose escalation, treatment with a dose of 10 mg should not be contemplated until patients have been on a daily dose of 5 mg for 4 to 6 weeks.
