DonepezilTurning Research Into PracticeYou are reading a certified PubDrug document. This document is complete and accurate to the best of the knowledge of the author and reviewer. This document cannot be edited without being unlocked by the PubDrug admin. Edits or updates may be recommended under the Discussion tab for this document. The half life of donepezil is 70 hours, allowing for its once daily dosing. The mean plasma clearance is 0.13 L/hr/kg. The volume of distribution is 12L/kg and it is 96% bound to proteins. The protein binding is delineated as 75% bound to albumin and 21% bound to alpha1- acid glycoprotein. 57% of the drug is recovered in the urine and 15% is recovered in the feces. 17% of the drug is found unchanged in the urine.