Dosing With Donepezil eMedTV Home The recommended dosing with donepezil starts at 5 mg once a day but may be increased to 10 mg after several weeks -- this gradual change decreases the risk of side effects. Donepezil comes in the form of an oral tablet, an orally disintegrating tablet, or an oral solution. Your dosing with donepezil should be taken every day at bedtime, with or without food.
