A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection - Full Text View - ClinicalTrials.gov First Received: November 16, 2007 Last Updated: February 18, 2009 History of Changes This clinical trial tests the hypotheses that 1) body decolonization of patients with recurrent community-associated (CA) MRSA infections and their household members and 2) environmental decolonization of the patients' households will significantly reduce the likelihood of recurrent CA-MRSA infection.The study population will comprise of persons suffering from recurrent CA-MRSA infection. Household members of this index subject will also be offered the chance to enroll in the study. For this clinical trial, all subjects will be randomized in a 2 x 2 design to test: 1) chlorhexidine body washes and nasal mupirocin ointment vs. usual care, and 2) environmental cleansing with ethanol spray and aggressive laundering vs. no environmental cleansing. Household members, should they consent, will also be enrolled into the study into the same treatment arm as index subjects . We will also perform selected secondary analyses, including studying the efficacy of the interventions at preventing infections in household members.
