MUPIROCIN - NASAL OINTMENT (Bactroban Nasal) side effects, medical uses, and drug interactions.Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage Apply half of the tube's contents to one nostril and the other half to the other nostril, usually in the morning and evening, or as directed by your doctor. Then gently squeeze your nostrils together and release. Repeat this for about 1 minute to spread the ointment. Throw away the tube after applying to both nostrils. Use this medication regularly in order to get the most benefit from it. Continue to use it for the full amount of time prescribed. Stopping this medication too early may allow bacteria to continue to grow. Avoid contact with your eyes. The manufacturer recommends not to use this medication with any other nasal products.