MUPIROCIN - TOPICAL CREAM (Bactroban) side effects, medical uses, and drug interactions.Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage Use this medication only on the skin. Clean and dry the affected area first. Then apply a small amount of cream to the area 3 times a day, or as directed by your doctor. You may cover the treated area with a bandage. Use this medication regularly in order to get the most benefit from it. Continue to use it for the full amount of time prescribed. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Avoid using this medication around your eyes, nose, or mouth unless otherwise directed by your doctor. Inform your doctor if your condition does not improve in 3-5 days.